Lack of pharmacokinetic drug interaction between oral posaconazole and caspofungin or micafungin.

@article{Krishna2011LackOP,
  title={Lack of pharmacokinetic drug interaction between oral posaconazole and caspofungin or micafungin.},
  author={Gopal Krishna and Donna Vickery and Lei Ma and Xin Yu and Carl F Noren and Edward Power and Eric Beresford and Matthew M Medlock},
  journal={Journal of clinical pharmacology},
  year={2011},
  volume={51 1},
  pages={84-92}
}
The objective of this phase 1, open-label, parallel, randomized study was to determine the effect of posaconazole on the pharmacokinetics of caspofungin and micafungin in 67 healthy subjects. Caspofungin (70 mg on day 1, 50 mg on days 2-14 once daily; 1-hour intravenous infusion) (cohort 1) or micafungin (150 mg once daily days 1-7; 1-hour IV infusion) (cohort 2) was administered alone or with posaconazole oral suspension 400 mg twice daily, on days 1 to 14 (cohort 1) or days 1 to 7 (cohort 2… CONTINUE READING

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