Lack of peroxisome proliferation in marmoset liver following treatment with ciprofibrate for 3 years.

@article{Graham1994LackOP,
  title={Lack of peroxisome proliferation in marmoset liver following treatment with ciprofibrate for 3 years.},
  author={Mark J. Graham and Sydney A Wilson and M A Winham and Andrew J. Spencer and J A Rees and Sally L. Old and Frank W. Bonner},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1994},
  volume={22 1},
  pages={58-64}
}
The effect of treatment of marmosets with ciprofibrate for 3 years on activities of hepatic enzymes, hepatic histomorphology, and ultrastructure were investigated. Male and female marmosets were dosed with ciprofibrate (2, 10, and 20 mg/kg) by oral gavage once daily for 3 years. No effect on liver weight (adjusted for body weight) or liver morphology was observed. The activities of catalase, glutathione peroxidase, alpha-glycerophosphate dehydrogenase, benzphetamine N-demethylase, and… CONTINUE READING

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