Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.

@article{Tkatchenko2009LackOP,
  title={Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.},
  author={Tatiana V. Tkatchenko and Ricardo A. Moreno-Rodriguez and Simon J. Conway and Jeffery D Molkentin and Roger R. Markwald and Andrei V Tkatchenko},
  journal={Physiological genomics},
  year={2009},
  volume={39 3},
  pages={160-8}
}
The Postn gene encodes protein periostin. During embryonic development, it is highly expressed in the outflow tract (OFT) endocardial cushions of the developing heart, which give rise to several structures of the mature heart including the aortic valve. Periostin was previously implicated in osteoblast differentiation, cancer metastasis, and tooth and bone development, but its role in cardiac OFT development is unclear. To elucidate the role that periostin plays in the developing heart we… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 30 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…