Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.

Abstract

Circulating levels of fibroblast growth factor 21 (FGF21), a metabolic regulator of glucose, lipid, and energy homeostasis, are elevated in obese diabetic subjects, raising questions about potential FGF21 resistance. Here we report tissue expression changes in FGF21 and its receptor components, and we describe the target-organ and whole-body responses to… (More)
DOI: 10.1210/en.2010-1262

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