Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

@article{Ernfors1994LackON,
  title={Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents},
  author={Patrik Ernfors and Kuo-Fen Lee and Jan Ku{\vc}era and Rudolf Jaenisch},
  journal={Cell},
  year={1994},
  volume={77},
  pages={503-512}
}
Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.
Brain-derived neurotrophic factor and neurotrophin-3 deficient mice were generated by gene targeting. The analysis of these mice has led to the characterization of their role in the survival of
Limb proprioceptive deficits without neuronal loss in transgenic mice overexpressing neurotrophin-3 in the developing nervous system.
TLDR
Novel roles for NT3 in differentiation of proprioceptive neurons, target invasion and formation of Ia projections which are independent from its effects on neuronal survival are suggested.
Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control
TLDR
It is suggested that increases in proprioceptive sensory neurons, spindles and gamma motoneurons, along with continued postnatal NT-3 overexpression in muscle significantly disrupt normal locomotor control.
Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control.
TLDR
It is suggested that increases in proprioceptive sensory neurons, spindles and gamma motoneurons, along with continued postnatal NT-3 overexpression in muscle significantly disrupt normal locomotor control.
Neurotrophin-3 Is a Survival Factor In Vivo for Early Mouse Trigeminal Neurons
TLDR
It is concluded that NT-3 acts principally as a peripherally derived survival factor for early trigeminal neurons in mice, which is caused, in large part, by increased cell death of embryonic neurons.
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It is shown that picomolar concentrations of three neurotrophins, brain-derived neurotrophic factor, neurotroph in-3 and neurotrophin-5, can prevent the death of cultured embryonic rat spinal motor neurons and may be physiological motor neuron growth factors.
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