Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

@article{Ernfors1994LackON,
  title={Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents},
  author={Patrik Ernfors and Kuo-Fen Lee and Jan Ku{\vc}era and Rudolf Jaenisch},
  journal={Cell},
  year={1994},
  volume={77},
  pages={503-512}
}
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807 Citations

Studies on the physiological role of brain-derived neurotrophic factor and neurotrophin-3 in knockout mice.
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Novel roles for NT3 in differentiation of proprioceptive neurons, target invasion and formation of Ia projections which are independent from its effects on neuronal survival are suggested.
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Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control
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It is suggested that increases in proprioceptive sensory neurons, spindles and gamma motoneurons, along with continued postnatal NT-3 overexpression in muscle significantly disrupt normal locomotor control.
Overexpression of neurotrophin-3 in skeletal muscle alters normal and injury-induced limb control.
TLDR
It is suggested that increases in proprioceptive sensory neurons, spindles and gamma motoneurons, along with continued postnatal NT-3 overexpression in muscle significantly disrupt normal locomotor control.
Neurotrophin-3 Is a Survival Factor In Vivo for Early Mouse Trigeminal Neurons
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It is concluded that NT-3 acts principally as a peripherally derived survival factor for early trigeminal neurons in mice, which is caused, in large part, by increased cell death of embryonic neurons.
Introduction of a Neurotrophin-3 Transgene into Muscle Selectively Rescues Proprioceptive Neurons in Mice Lacking Endogenous Neurotrophin-3
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References

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It is shown that picomolar concentrations of three neurotrophins, brain-derived neurotrophic factor, neurotroph in-3 and neurotrophin-5, can prevent the death of cultured embryonic rat spinal motor neurons and may be physiological motor neuron growth factors.
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