Lack of mutations of type 1 11beta-hydroxysteroid dehydrogenase gene in patients with abdominal obesity.

@article{Caramelli2001LackOM,
  title={Lack of mutations of type 1 11beta-hydroxysteroid dehydrogenase gene in patients with abdominal obesity.},
  author={Elisabetta Caramelli and Pierluigi Strippoli and T Di Giacomi and Catleen Tietz and Paolo Carinci and Rigoberto Pasquali},
  journal={Endocrine research},
  year={2001},
  volume={27 1-2},
  pages={
          47-61
        }
}
There is increasing evidence that in human obesity, particularly the abdominal phenotype, the activity of the hypothalamic-pituitary-adrenal (HPA) axis is disregulated. At least two distinct alterations have been reported: one is characterized by several neuroendocrine abnormalities and hyperresponsiveness of the HPA axis to different neuropeptides, the other is characterized by elevated cortisol traffic and probably by supranormal cortisol production. The 11beta-hydroxysteroid dehydrogenase… CONTINUE READING
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