Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase.

Abstract

Activation of vitamin D requires hepatic 25-hydroxylation and renal 1alpha-hydroxylation. Defects in renal P450c1alpha are well-described, but few patients with defective vitamin D 25-hydroxylation are reported. The cytochrome P450 enzymes CYP2D6 and CYP27 are potential 25-hydroxylases. We sequenced both genes in two reported families with hepatic 25… (More)

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@article{Lin2003LackOM, title={Lack of mutations in CYP2D6 and CYP27 in patients with apparent deficiency of vitamin D 25-hydroxylase.}, author={Chin Jia Lin and Andrea Dardis and Sujeewa D. Wijesuriya and Mohamed Ahmed Abdullah and Samuel J. Casella and Walter Miller}, journal={Molecular genetics and metabolism}, year={2003}, volume={80 4}, pages={469-72} }