Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure

@article{Sakuma2016LackOM,
  title={Lack of motor recovery after prolonged denervation of the neuromuscular junction is not due to regenerative failure},
  author={Miyuki Sakuma and Grzegorz Gorski and Shu-Hsien Sheu and Stella Lee and Lee B. Barrett and Bhagat Singh and Takao Omura and Alban Latr{\'e}moli{\`e}re and Clifford J. Woolf},
  journal={European Journal of Neuroscience},
  year={2016},
  volume={43}
}
Motor axons in peripheral nerves have the capacity to regenerate after injury. However, full functional motor recovery rarely occurs clinically, and this depends on the nature and location of the injury. Recent preclinical findings suggest that there may be a time after nerve injury where, while regrowth to the muscle successfully occurs, there is nevertheless a failure to re‐establish motor function, suggesting a possible critical period for synapse reformation. We have now examined the… Expand
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