Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation.

@article{Mi2012LackOM,
  title={Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation.},
  author={Qing-Sheng Mi and Ying-ping Xu and Rui-Qun Qi and Yu-ling Shi and Li Zhou},
  journal={Experimental dermatology},
  year={2012},
  volume={21 11},
  pages={876-7}
}
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that repress target genes at post-transcriptional level. Langerhans cells (LCs) are skin-residential dendritic cells (DCs) with a life cycle distinct from other types of DCs. miRNA deficiency interrupts the homoeostasis and function of epidermal LCs, suggesting the critical roles of miRNAs in LC development and function. However, the roles of individual miRNAs in regulating LC development and function remain completely… CONTINUE READING
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