Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer

@article{Ameziane2009LackOL,
  title={Lack of large genomic deletions in BRIP1, PALB2, and FANCD2 genes in BRCA1/2 negative familial breast cancer},
  author={Najim Ameziane and Ans M. W. van den Ouweland and Muriel A. Adank and Raymond N. C. P. Vijzelaar and Abdellatif Errami and Josephine C. Dorsman and Hans Joenje and Hanne Meijers-Heijboer and Quinten Waisfisz},
  journal={Breast Cancer Research and Treatment},
  year={2009},
  volume={118},
  pages={651-653}
}
Breast cancer (BC) is the most common malignancy in women worldwide. It is estimated that 5–10% of all BC cases may be caused by germline mutations in breast cancer susceptibility genes [19, 21]. BRCA1 and BRCA2 are the major known BC susceptibility genes accounting for *16% of the familial BC cases [2]. Other BC susceptibility genes include TP53 [16], PTEN [15], ATM [24], LKB1/STK11 [8], CHEK2 [28], BRIP1/FANCJ [27], and PALB2/FANCN [22]. However to date, the majority of familial BC cases can… CONTINUE READING