Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.

@article{Schmidt1998LackOI,
  title={Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.},
  author={Manuel Schmidt and Stefan Nagel and J Proba and Christian Thiede and Markus Ritter and Jeffrey F. Waring and Frank Rosenbauer and Dieter Huhn and Burghardt Wittig and Ivan Horak and Andreas Neubauer},
  journal={Blood},
  year={1998},
  volume={91 1},
  pages={22-9}
}
Interferon consensus sequence binding protein (ICSBP) was first identified as a transcription factor of the interferon (IFN) regulatory factor family (IRF) which regulates expression of IFN-dependent genes by binding to DNA at specific sites, IFN-stimulated responsive elements. Analysis of ICSBP-deficient mice showed hematologic alterations similar to chronic myelogenous leukemia (CML) in humans and suggested a novel role for ICSBP in regulating proliferation and differentiation of… CONTINUE READING

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