Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease.

@article{Mayer1990LackOI,
  title={Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease.},
  author={Lloyd F Mayer and Dieter Eisenhardt},
  journal={The Journal of clinical investigation},
  year={1990},
  volume={86 4},
  pages={
          1255-60
        }
}
The mechanisms underlying the chronic unrelenting inflammatory response seen in inflammatory bowel disease (IBD) are poorly understood. We have recently proposed a novel role for the normal intestinal enterocyte, that of antigen presenting cell. However, in contrast to conventional antigen presenting cells, normal enterocytes appear to selectively activate CD8+ antigen nonspecific suppressor T cells. To determine whether failure of this process may be occurring in inflammatory bowel disease… CONTINUE READING
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