Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.

@article{Jaeschke2010LackOI,
  title={Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.},
  author={Holger Jaeschke and Sandra M Mueller and M. Eszlinger and R. Paschke},
  journal={Clinical endocrinology},
  year={2010},
  volume={73 6},
  pages={
          815-20
        }
}
OBJECTIVE Constitutively activating mutations (CAMs) of the TSHR are the major cause for nonautoimmune hyperthyroidism. Re-examination of constitutive activity previously determined in CHO cell lines recently demonstrated the caveats for the in vitro determination of constitutive TSHR activity, which leads to false positive conclusions regarding the molecular origin of hyperthyroidism or hot thyroid carcinomas. DESIGN Mutations L677V and T620I identified in hot thyroid carcinomas were… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

Molecular diagnostics and predictors in thyroid cancer.

  • Thyroid : official journal of the American Thyroid Association
  • 2009

family member with a second activating somatic mutation. Thyroid, 18, 499–508

S. Mueller, H. I. Gozu, R Bircan
  • 2009

Poly - morphism of a variant human thyrotropin receptor ( hTSHR ) gene

H. I. Gozu, S. Mueller, R. Bircan
  • Thyroid
  • 2008

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