• Corpus ID: 41537390

Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.

  title={Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.},
  author={Joseph Fialip and A Porteix and H Marty and Alain Eschalier and Pierre Duch{\^e}ne-Marullaz},
  journal={Archives internationales de pharmacodynamie et de therapie},
The analgesic effect of caffeine used alone and in combination with dipyrone and butalbital was evaluated after oral administration in mice, using two different pain tests: the hot plate test and the phenylbenzoquinone-induced writhing test. Neither caffeine (5 to 200 mg/kg) nor butalbital (10 and 20 mg/kg) (20 mg/kg was the highest dose that did not induce sleep) produced a significant antinociceptive effect, whereas dipyrone was active from 400 mg/kg in the hot plate test and from 50 mg/kg in… 
Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats.
It is reported here that caffeine (17.8 and 31.6 mg/kg) is able to potentiate the antinociceptive effect of ibuprofen, and this investigation showed that six combinations presented effects of potentiation and twelve combinations only showed antinOCiceptive effects not different from that of ib uprofen alone.
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms
An integral involvement of noradrenergic mechanisms in the antinociceptive action of caffeine in the rat hot‐plate and formalin tests and in locomotor stimulation is suggested, but the nature of this involvement differs for the 3 end points.
Synergism of caffdne on antinociceptive efiects of metamizole
This study has shown that djuvant caffeine is able to change the effect of metamizole in the inflammatarv ~ain model, in which caffeine also presents an antinocicepti~effect.
Effects of Reference Analgesics and Psychoactive Drugs on the Noxious Heat Threshold of Mice Measured by an Increasing‐Temperature Water Bath
It is concluded that the increasing‐temperature water bath is suitable for studying the thermal antinociceptive effects of morphine and diclofenac as well as the morphine‐sparing action of dicL ofenac, metamizol, droperidol and diazepam.
A review of the pharmacokinetic and pharmacodynamic factors in the potentiation of the antinociceptive effect of nonsteroidal anti-inflammatory drugs by caffeine.
Because caffeine shifts the effect-compartment concentration-effect relation of NSAIDs to the left and this relationship is sigmoidal, there is no potentiation if the NSAID concentrations are too high or too low with respect to EC(50).
Methylxanthines and pain.
  • J. Sawynok
  • Medicine
    Handbook of experimental pharmacology
  • 2011
Caffeine clearly exhibits complex effects on pain transmission; knowledge of such effects is important for understanding adjuvant analgesia as well as considering situations in which dietary caffeine intake may have an impact on analgesic regimens.
Sinergismo de la cafeína sobre los efectos antinociceptivos del metamizol
Adjuvant caffeine is able to change the effect of metamizole in the inflammatory pain model, in which caffeine also presents an antinociceptive effect.
Effect of coadministration of caffeine and either adenosine agonists or cyclic nucleotides on ketorolac analgesia.
The results suggest that caffeine potentiation of ketorolac-induced antinociception is mediated, at least partially, by a local increase in cGMP and rule out the participation of adenosine receptor blockade.