• Corpus ID: 41537390

Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.

@article{Fialip1989LackOI,
  title={Lack of importance of caffeine as an analgesic adjuvant of dipyrone in mice.},
  author={Joseph Fialip and A Porteix and H Marty and Alain Eschalier and Pierre Duch{\^e}ne-Marullaz},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1989},
  volume={302},
  pages={
          86-95
        }
}
The analgesic effect of caffeine used alone and in combination with dipyrone and butalbital was evaluated after oral administration in mice, using two different pain tests: the hot plate test and the phenylbenzoquinone-induced writhing test. Neither caffeine (5 to 200 mg/kg) nor butalbital (10 and 20 mg/kg) (20 mg/kg was the highest dose that did not induce sleep) produced a significant antinociceptive effect, whereas dipyrone was active from 400 mg/kg in the hot plate test and from 50 mg/kg in… 
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