Lack of impact of artesunate on the disposition kinetics of sulfadoxine/pyrimethamine when the two drugs are concomitantly administered

Abstract

To determine the effect of artesunate (AT) on the disposition kinetics of sulfadoxine/pyrimethamine (SP) in humans. In a randomized cross-over study, 16 healthy volunteers were given a dose of three SP tablets containing 500 mg of sulfadoxine (SDX) and 25 mg of pyrimethamine (PYR) (=SP group), while the second arm received three SP tablets + two AT tablets… (More)
DOI: 10.1007/s00228-007-0278-4

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@article{Minzi2007LackOI, title={Lack of impact of artesunate on the disposition kinetics of sulfadoxine/pyrimethamine when the two drugs are concomitantly administered}, author={Omary M. S. Minzi and Ankur Gupta and Antelmo Haule and Godeliver A B Kagashe and Amos Y Massele and Lars L. Gustafsson}, journal={European Journal of Clinical Pharmacology}, year={2007}, volume={63}, pages={457-462} }