Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats.

@article{MonteiroRiviere2012LackOH,
  title={Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats.},
  author={Nancy A Monteiro-Riviere and Keith E Linder and Alfred O. Inman and John G Saathoff and X R Xia and Jim E Riviere},
  journal={Journal of toxicology and environmental health. Part A},
  year={2012},
  volume={75 7},
  pages={367-73}
}
Hydroxylated fullerenes (C₆₀OH(x)) or fullerols are water-soluble carbon nanoparticles that have been explored for potential therapeutic applications. This study assesses acute in vivo tolerance in 8-wk-old female Sprague-Dawley rats to intravenous (iv) administration of 10 mg/kg of well-characterized C₆₀(OH)₃₀. Complete histopathology and clinical chemistries are assessed at 8, 24, and 48 h after dosing. Minor histopathology changes are seen, primarily in one animal. No clinically significant… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
4 Citations
16 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Fullerenol: A new nanopharmaceutic? Arch

  • A. Dordević, G. Bogdanović
  • Oncol. 16: 42–45.
  • 2008
Highly Influential
4 Excerpts

Guide for the care and use of laboratory animals

  • Institute of Laboratory Animal Resources.
  • Washington, DC: National Academies Press.
  • 1996
Highly Influential
3 Excerpts

Protective effects of fullerenol on carbon tetrachloride-induced acute hepatotoxicity and nephrotoxicity in rats

  • R. Liu, W. X. Li, G. T. Xu, Q. N. Li
  • Carbon 48: 1338–96.
  • 2010

Fullerenol : A new nanopharmaceutic ?

  • R. Injac, M. Boskovic, +4 authors B. Strukelj
  • Arch . Oncol
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…