Lack of heme synthesis in a free-living eukaryote.

  title={Lack of heme synthesis in a free-living eukaryote.},
  author={Anita U. Rao and Lynn K. Carta and Emmanuel Lesuisse and Iqbal Hamza},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 12},
In most free-living eukaryotes studied thus far, heme is synthesized from a series of intermediates through a well defined evolutionarily conserved pathway. We found that free-living worms, including the model genetic organism Caenorhabditis elegans, and parasitic helminths are unable to synthesize heme de novo, even though these animals contain hemoproteins that function in key biological processes. Radioisotope, fluorescence labeling, and heme analog studies suggest that C. elegans acquires… CONTINUE READING
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