Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver

@article{Hiskett2008LackOG,
  title={Lack of glucokinase regulatory protein expression may contribute to low glucokinase activity in feline liver},
  author={Erin K. Hiskett and Orn-usa Suwitheechon and Sara Lindbloom-Hawley and Daniel L. Boyle and Thomas Schermerhorn},
  journal={Veterinary Research Communications},
  year={2008},
  volume={33},
  pages={227-240}
}
In most mammals, glucokinase (GK) acts as a hepatic “glucose sensor” that permits hepatic metabolism to respond appropriately to changes in plasma glucose concentrations. GK activity is potently regulated by the glucokinase regulatory protein (GKRP), which is encoded by the GCKR gene. GKRP binds GK in the nucleus and inhibits its activity. GK becomes active when it is released from GKRP and translocates to the cytosol. Low glucokinase (GK) activity is reported to be a principal feature of… CONTINUE READING
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