Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males.

@article{Arruda2001LackOG,
  title={Lack of germline transmission of vector sequences following systemic administration of recombinant AAV-2 vector in males.},
  author={Valder R Arruda and Paul A. Fields and Roy Milner and L A Wainwright and M P De Miguel and Peter J Donovan and Roland W. Herzog and Timothy C Nichols and Jaclyn A Biegel and Morteza Razavi and Michael M. Dake and Dale Huff and Alan W. Flake and Linda Couto and Mark A. Kay and K. A. High},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2001},
  volume={4 6},
  pages={586-92}
}
A potential consequence of systemic administration of viral vectors is the inadvertent introduction of foreign DNA into recipient germ cells. To evaluate the safety of in vivo recombinant adeno-associated virus (rAAV) mediated gene transfer approaches for hemophilia B, we explored the risk of germline transmission of vector sequences following intramuscular (IM) injection of rAAV in four species of male animals (mouse, rat, rabbit and dog). In vector biodistribution studies in mice and rats… CONTINUE READING
41 Citations
28 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Evidence for gene transfer and expression of blood coagulation factor IX in patients with severe hemophilia B treated with an AAV

  • Kay, A M.
  • vector. Nat. Genet
  • 2000
2 Excerpts

Human inheritable genetic modifications : Assessing scientific , ethical , religious , and policy issues

  • J. W. Gordon
  • 2000

Human inheritable genetic modifications: Assessing scientific, ethical, religious, and policy issues, http://www.aaas.org/spp/ dspp/sfrl/germline/main.htm

  • M. Frankel, A. Chapman
  • 2000
1 Excerpt

Endogenous insertional mutations in the human germ line

  • H. H. Kazazian
  • Nat. Genet
  • 1999
1 Excerpt

Gene therapy and the germline

  • S. Epstein, S. Bauer, A. Miller, A. Pilaro, P. Noguchi
  • Nat . Med .
  • 1999

Similar Papers

Loading similar papers…