Lack of genetic restriction by a potential anti-idiotype vaccine for type B viral hepatitis.

@article{Kennedy1986LackOG,
  title={Lack of genetic restriction by a potential anti-idiotype vaccine for type B viral hepatitis.},
  author={Ronald C. Kennedy and Jorg W. Eichberg and Gordon R. Dreesman},
  journal={Virology},
  year={1986},
  volume={148 2},
  pages={369-74}
}
Anti-idiotype (anti-Id) reagents that bear an internal image capable of mimicking hepatitis B surface antigen (HBsAg) were used to induce an antibody to HBsAg (anti-HBs) response in both rabbits and chimpanzees. The anti-idiotype induced antibody response produced in rabbits recognized HBsAg determinants associated with the induction of protective immunity against hepatitis B virus (HBV). Attesting further to the specificity was the binding of the rabbit anti-idiotype to the anti-idiotype… CONTINUE READING

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