Lack of genetic association among coat colors, progressive retinal atrophy and polycystic kidney disease in Persian cats

@article{Rah2006LackOG,
  title={Lack of genetic association among coat colors, progressive retinal atrophy and polycystic kidney disease in Persian cats},
  author={Hyungchul Rah and David J Maggs and Leslie A. Lyons},
  journal={Journal of Feline Medicine and Surgery},
  year={2006},
  volume={8},
  pages={357 - 360}
}

Tables from this paper

Early-Onset Progressive Retinal Atrophy Associated with an IQCB1 Variant in African Black-Footed Cats (Felis nigripes)

Testing in additional affected cats confirmed that cats homozygous for a 2 base pair deletion within IQ calmodulin-binding motif-containing protein-1 (IQCB1), the gene that encodes for nephrocystin-5 (NPHP5), had vision loss.

Whole genome sequencing in cats, identifies new models for blindness in AIPL1 and somite segmentation in HES7

This study is the first effort of the 99 Lives Cat Genome Sequencing Initiative to identify disease - causing variants in the domestic cat using WGS and suggests the HES7 variant should further calibrate the somite segmentation clock.

Whole genome sequencing in cats , identifies new models for blindness in AIPL 1 and somite segmentation in HES 7

This study represents the first effort of the 99 Lives Cat Genome Sequencing Initiative to identify disease causing variants in the domestic cat using WGS, and the HES7 variant should further calibrate the somite segmentation clock.

A clinical report of entangled neonates' umbilical cord with queen's fur in Persian cat.

References

SHOWING 1-10 OF 23 REFERENCES

Early-onset, autosomal recessive, progressive retinal atrophy in Persian cats.

characterized in this study was an autosomal recessive, early-onset, retinal degenerative disease in Persian cats that is likely to be more prevalent in this breed than previously suspected and may identify a new gene or provide biological insight into some forms of early-ONSet retinitis pigmentosa in humans and genetic retinal deterioration in other species.

[Progressive retinal atrophy in Abyssinian and Somali cats in the Netherlands (1981-2001)].

A large-scale and systematic examination programme for hereditary eye disease will be necessary to assess the incidence of PRA in the Dutch population of Abyssinian and Somali cats as a whole, and to provide a basis for a preventive breeding programme.

Feline polycystic kidney disease mutation identified in PKD1.

The data suggest that the stop mutation causes feline PKD, providing a test to identify cats that will develop PKD and demonstrating that the domestic cat is an ideal model for human PKD.

Hereditary progressive retinal atrophy in the Abyssinian cat

Genetic analysis indicates that PRA in the Abyssinian cat is caused by an autosomal recessive gene.

Progressive retinal atrophy: a model for retinitis pigmentosa in companion animals.

Of the various recessively inherited forms of PRA in the dog, that in the Irish setter is due to a nonsense mutation in the gene encoding cGMP-PDE-beta subunit, which is also known to cause a proportion of human RP cases.

Chocolate coated cats: TYRP1 mutations for brown color in domestic cats

The complete coding sequence of feline TYRP1 and a portion of the 5′ UTR was analyzed by direct sequencing of genomic DNA of wild-type and brown color variant cats and 16 single nucleotide polymorphisms (SNPs) were identified.

Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus).

All cats that had 'pointed' or the Burmese coat colour phenotype were homozygous for the corresponding mutations, respectively, suggesting that these phenotypes are a result of the identified mutations or unidentified mutations that are in linkage disequilibrium.

Autosomal dominant progressive retinal atrophy in Abyssinian cats.

It is concluded that these are two distinct conditions, one occurring at an early age in kittens with an autosome dominant mode of inheritance, the other occurring in young adult cats due to an autosomal recessive gene.

Molecular Genetics and Evolution of Melanism in the Cat Family

Retinal degeneration in the dog and cat.

  • N. Millichamp
  • Medicine, Biology
    The Veterinary clinics of North America. Small animal practice
  • 1990