Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model.

@article{Clark2013LackOG,
  title={Lack of galectin-1 or galectin-3 alters B cell deletion and anergy in an autoantibody transgene model.},
  author={Amy G. Clark and Melissa L Weston and Mary H Foster},
  journal={Glycobiology},
  year={2013},
  volume={23 7},
  pages={893-903}
}
Members of the galectin family of proteins have been shown to regulate the development and the function of immune cells. We previously identified the increased expression of galectin-1 and galectin-3 mRNA and protein in anergic B cells relative to their naïve counterparts. To investigate the role of these galectins in maintaining B cell tolerance, we crossed mice deficient in galectin-1 or galectin-3 with mice bearing a lupus autoantigen-binding transgenic (Tg) B cell receptor, using a model… CONTINUE READING