Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.

@article{McLaughlin2007LackOF,
  title={Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice.},
  author={Precious J. McLaughlin and Benjamin B. Bakall and Jiwon Choi and Zhonglin Liu and Takako Sasaki and Elaine C. Davis and Alan D. Marmorstein and Lihua Y. Marmorstein},
  journal={Human molecular genetics},
  year={2007},
  volume={16 24},
  pages={3059-70}
}
A mutation in the EFEMP1 gene causes Malattia Leventinese, an inherited macular degenerative disease with strong similarities to age-related macular degeneration. EFEMP1 encodes fibulin-3, an extracellular matrix protein of unknown function. To investigate its biological role, the murine Efemp1 gene was inactivated through targeted disruption. Efemp1(-/-) mice exhibited reduced reproductivity, and displayed an early onset of aging-associated phenotypes including reduced lifespan, decreased body… CONTINUE READING
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