Lack of evidence to support the association of the human prion gene with schizophrenia

  title={Lack of evidence to support the association of the human prion gene with schizophrenia},
  author={M-T Tsai and Y Su and Y. Chen and Cheng-Hsu Chen},
  journal={Molecular Psychiatry},
Recently a new variant of Creutzfeldt–Jakob disease, a human prion disease, with prominent psychiatric manifestations in the early stage was identified, suggesting that human prion disease may be associated with mental disorders. Furthermore, a novel missense mutation with asparagine-to-serine substitution at codon 171 of the human prion gene (N171S) was identified in a family with severe psychiatric symptoms. This finding provides further clue that the prion gene may be a susceptibility gene… CONTINUE READING


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