Lack of evidence to support the association of the human prion gene with schizophrenia

@article{Tsai2001LackOE,
  title={Lack of evidence to support the association of the human prion gene with schizophrenia},
  author={M-T Tsai and Y Su and Y. Chen and Cheng-Hsu Chen},
  journal={Molecular Psychiatry},
  year={2001},
  volume={6},
  pages={74-78}
}
Recently a new variant of Creutzfeldt–Jakob disease, a human prion disease, with prominent psychiatric manifestations in the early stage was identified, suggesting that human prion disease may be associated with mental disorders. Furthermore, a novel missense mutation with asparagine-to-serine substitution at codon 171 of the human prion gene (N171S) was identified in a family with severe psychiatric symptoms. This finding provides further clue that the prion gene may be a susceptibility gene… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Polymorphism distribution of prion protein codon 117, 129 and 171 in Taiwan

European Journal of Epidemiology • 2007
View 10 Excerpts
Highly Influenced

Report about four novel mutations in the prion protein gene.

Dementia and geriatric cognitive disorders • 2013

Molecular Pathology of Human Prion Diseases

International journal of molecular sciences • 2009
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 30 references

plete genomic sequence and analysis of the prion protein gene region from three mammalian species

IY Lee, D Westaway, +3 authors L Chen
Genome Res • 1998

A prion-linked psychiatric disorder

RR Brentani
Nature • 1997

BSE and human prion disease.

The British journal of psychiatry : the journal of mental science • 1997

Psychosis in neurodegenerative disease

Hsueh Ko Hsueh Tsa Chih
Semin Clin Neuropsychiatry • 1997

Similar Papers

Loading similar papers…