Lack of evidence of WNT3A as a candidate gene for congenital vertebral malformations

@article{Ghebranious2007LackOE,
  title={Lack of evidence of WNT3A as a candidate gene for congenital vertebral malformations},
  author={Nader R Ghebranious and Cathleen L. Raggio and Robert D. Blank and Elizabeth W. McPherson and James K. Burmester and Lynn C. Ivacic and Kristen J Rasmussen and Jennifer Kislow and Ingrid Glurich and F Stig Jacobsen and Thomas Faciszewski and Richard M. Pauli and Oheneba B Boachie-Adjei and Philip F Giampietro},
  journal={Scoliosis},
  year={2007},
  volume={2},
  pages={13 - 13}
}
BACKGROUND Prior investigations have not identified a major locus for vertebral malformations, providing evidence that there is genetic heterogeneity for this condition. WNT3A has recently been identified as a negative regulator of Notch signaling and somitogenesis. Mice with mutations in Wnt3a develop caudal vertebral malformations. Because congenital vertebral malformations represent a sporadic occurrence, linkage approaches to identify genes associated with human vertebral development are… CONTINUE READING