Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis.

@article{Deguti2003LackOE,
  title={Lack of evidence for the pathogenic role of iron and HFE gene mutations in Brazilian patients with nonalcoholic steatohepatitis.},
  author={Marta Mitiko Deguti and Aytan Miranda Sipahi and Luiz Carlos da Costa Gayotto and Selma Aliotti Pal{\'a}cios and Paulo R L Bittencourt and Anna Carla Goldberg and Ant{\^o}nio At{\'i}lio Laudanna and Flair Jos{\'e} Carrilho and Eduardo L. R Cançado},
  journal={Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas},
  year={2003},
  volume={36 6},
  pages={739-45}
}
The hypothesis of the role of iron overload associated with HFE gene mutations in the pathogenesis of nonalcoholic steatohepatitis (NASH) has been raised in recent years. In the present study, biochemical and histopathological evidence of iron overload and HFE mutations was investigated in NASH patients. Thirty-two NASH patients, 19 females (59%), average 49.2 years, 72% Caucasians, 12% Mulattoes and 12% Asians, were submitted to serum aminotransferase and iron profile determinations. Liver… CONTINUE READING