Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

@article{Shilling2012LackOE,
  title={Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.},
  author={Dustin J. Shilling and Don-On Daniel Mak and David E. Kang and J. Kevin Foskett},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 14},
  pages={
          10933-44
        }
}
Familial Alzheimer disease (FAD) is linked to mutations in the presenilin (PS) homologs. FAD mutant PS expression has several cellular consequences, including exaggerated intracellular Ca(2+) ([Ca(2+)](i)) signaling due to enhanced agonist sensitivity and increased magnitude of [Ca(2+)](i) signals. The mechanisms underlying these phenomena remain controversial. It has been proposed that PSs are constitutively active, passive endoplasmic reticulum (ER) Ca(2+) leak channels and that FAD PS… CONTINUE READING
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References

Publications referenced by this paper.
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Role of presenilins in neuronal calcium homeostasis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 6 Excerpts
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Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 6 Excerpts
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