Lack of evidence for feminization of males exposed to spironolactone in utero: A systematic review

  title={Lack of evidence for feminization of males exposed to spironolactone in utero: A systematic review},
  author={Walter Liszewski and Christina L Boull},
  journal={Journal of the American Academy of Dermatology},
To the Editor: Because of its antiandrogen properties, spironolactone is accepted and used as a therapeutic option for hormonal acne. Its risk in women of childbearing potential is conflicting. While it has been shown to cause feminization of male animals exposed in utero, it is also approved by the US Food and Drug Administration to treat edema in pregnant women (25-200 mg/day). To help dermatologists understand the risks of spironolactone use in pregnancy, we performed a qualitative… Expand

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