Lack of evidence for feminization of males exposed to spironolactone in utero: A systematic review

@article{Liszewski2019LackOE,
  title={Lack of evidence for feminization of males exposed to spironolactone in utero: A systematic review},
  author={Walter Liszewski and Christina L Boull},
  journal={Journal of the American Academy of Dermatology},
  year={2019},
  volume={80},
  pages={1147–1148}
}
To the Editor: Because of its antiandrogen properties, spironolactone is accepted and used as a therapeutic option for hormonal acne. Its risk in women of childbearing potential is conflicting. While it has been shown to cause feminization of male animals exposed in utero, it is also approved by the US Food and Drug Administration to treat edema in pregnant women (25-200 mg/day). To help dermatologists understand the risks of spironolactone use in pregnancy, we performed a qualitative… Expand

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References

SHOWING 1-10 OF 15 REFERENCES
Lack of effect of spironolactone on male genital development.
TLDR
No evidence of an antiandrogen action of spironolactone was found in the experimental model used, and the male members of the resultant litters were examined for evidence of pseudohermaphroditism. Expand
Modifications of the gonadal function in the adult rat after fetal exposure to spironolactone.
TLDR
It is demonstrated that in utero exposure to SPL leads to endocrine dysfunctions that persist into adulthood, characterized in males by hypoprolactinemia, reduced weights of accessory sex organs, and a suggestion of functional modifications of androgen receptors. Expand
Disturbances in sexual differentiation of rat foetuses following spironolactone treatment.
TLDR
The degree of feminization of the male foetuses which is achieved under the influence of sp (40 mg/day) is the same as that which can be induced by 1--3 mg cyproterone acetate. Expand
Alcohol use prior to pregnancy recognition.
TLDR
Half of all pregnant women in this study drank alcohol during the 3 months preceding pregnancy recognition, with 1 in 20 drinking at moderate to heavy levels, and the majority did not know they were pregnant until after the fourth week of gestation. Expand
Idiopathic aldosteronism in pregnancy.
This is the first reported case of the idiopathic type of primary aldosteronism in pregnancy. The severely hypertensive patient was unresponsive to treatment with high doses of four antihypertensiveExpand
Gitelman syndrome during pregnancy: a therapeutic challenge
TLDR
A female patient diagnosed of Gitelman disease who suffered from severe hypokalemia and hypomagnesemia during pregnancy is reported and the therapeutic approach and materno-fetal outcome is discussed. Expand
of Health and Human Services website
  • Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. Available at: https://www.fda.gov/downloads/ drugs/guidances/ucm078932.pdf. Accessed May ,
  • 2018
Ambiguous genitalia in a newborn with spironolactone exposure [abstract]. Presented at the 93rd Annual Meeting of the Endocrine Society
  • 2011
  • 2008
...
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2
...