Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism.

@article{Ramoz2006LackOE,
  title={Lack of evidence for association of the serotonin transporter gene SLC6A4 with autism.},
  author={Nicolas Ramoz and Jennifer G. Reichert and Thomas E Corwin and Christopher J Smith and Jeremy M. Silverman and Eric Hollander and Joseph D. Buxbaum},
  journal={Biological psychiatry},
  year={2006},
  volume={60 2},
  pages={186-91}
}
BACKGROUND The serotonin transporter (5-HTT) has long been considered likely to play a role in autism. Hyperserotonemia has been consistently found in a proportion of autistic patients, and the use of selective serotonin reuptake inhibitors (SSRIs) can have a positive effect in treating some symptoms of autism. Specific variants of the 5-HTT gene, SLC6A4, especially the insertion-deletion 5-HTTLPR promoter locus, have been found to modulate its expression and transporter function. METHODS We… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Similar Papers

Loading similar papers…