Lack of evidence for a role of mast cell degranulation in acute hypoxia/reoxygenation-induced injury in the isolated rat heart.

@article{Haaster1996LackOE,
  title={Lack of evidence for a role of mast cell degranulation in acute hypoxia/reoxygenation-induced injury in the isolated rat heart.},
  author={C M van Haaster and Wim J.M. Engels and Adrian M. Duijvestijn and Paul Lemmens and Gerard Hornstra and Ger J. van der Vusse},
  journal={Journal of molecular and cellular cardiology},
  year={1996},
  volume={28 2},
  pages={363-73}
}
In the present study, we evaluated the potential role of mast cell degranulation in acute hypoxia/reoxygenation-induced injury to cardiomyocytes in the isolated rat heart. Histamine release was determined to delineate the extent of mast cell degranulation, whereas the release of creatine kinase (CK) and lactate dehydrogenase (LDH) was assessed to quantitate the extent of irreversible injury to cardiomyocytes. The suitability of peroxidase (PO) as a marker for mast cell degranulation was also… CONTINUE READING