Lack of evidence for a role for the lipoxygenase pathway in increases in cytosolic calcium evoked by ADP and arachidonic acid in human platelets.

@article{Vindlacheruvu1991LackOE,
  title={Lack of evidence for a role for the lipoxygenase pathway in increases in cytosolic calcium evoked by ADP and arachidonic acid in human platelets.},
  author={R. R. Vindlacheruvu and Timothy P. Rink and Stewart O. Sage},
  journal={FEBS letters},
  year={1991},
  volume={292 1-2},
  pages={196-200}
}
We have investigated the possibility that metabolism of arachidonic acid by the lipoxygenase pathway contributes to ADP-evoked rises in [Ca2+], in human platelets. 30 microM BW A4C did not affect ADP-evoked Ca2+ signals, but inhibited 12-lipoxygenase activity in platelet homogenates. Another lipoxygenase inhibitor, MK 866 was similarly without effect on ADP… CONTINUE READING