Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.

@article{Wik2013LackOE,
  title={Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.},
  author={Elisabeth Wik and Maria B. R{\ae}der and Camilla Krakstad and Jone Trovik and Even Birkeland and Erling Andre Hoivik and Siv Mjos and Henrica Maria Johanna Werner and Monica Mannelqvist and Ingunn Marie Stefansson and Anne Margrete Oyan and Karl Henning Kalland and Lars Andreas Akslen and Helga Birgitte Salvesen},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 5},
  pages={1094-105}
}
PURPOSE We hypothesized that estrogen receptor-α (ER-α) status in endometrial carcinomas, associated with poor prognosis, is reflected in transcriptional signatures suggesting targets for new therapy. EXPERIMENTAL DESIGN Endometrial carcinoma samples in a primary investigation cohort (n = 76) and three independent validation cohorts (n = 155/286/111) were analyzed through integrated molecular profiling. Biomarkers were assessed by immunohistochemistry (IHC), DNA oligonucleotide microarray… CONTINUE READING
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