Lack of enhancement of chemical mutagenesis by saccharin in the Salmonella assay

Abstract

A purified batch of the artificial sweetener saccharin (S-1022) was assayed for mutagenicity and comutagenicity by the Ames Salmonella assay system. Saccharin was not mutagenic and failed to enhance the mutagenic activity induced by a wide variety of known mutagens. These results do not argue against the tumor-promoter-like activity of saccharin but only… (More)
DOI: 10.1007/BF00333621

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