Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury.

@article{Forbes2007LackOE,
  title={Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury.},
  author={Michael S. Forbes and Barbara A. Thornhill and Matthew H Park and Robert L. Chevalier},
  journal={The American journal of pathology},
  year={2007},
  volume={170 1},
  pages={87-99}
}
Because endothelial nitric-oxide synthase (eNOS) is generally considered protective against renal injury, we examined eNOS knockout mice for kidney pathology. In 80% of the adults examined, the renal surface was marked by distinct indented scars containing crowded small glomeruli but lacking attached tubules. Although vasculature was intact in the scars, Bowman's space was dilated and glomerular tufts were degenerated. The atubular glomeruli were embedded in a dense interstitial matrix composed… CONTINUE READING

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