Lack of endocrine systemic side effects after topical application of spironolactone in man

@article{Rey1988LackOE,
  title={Lack of endocrine systemic side effects after topical application of spironolactone in man},
  author={F Rey and C. Valterio and Luigi Locatelli and Albert Adrien Ramelet and J. P. Felber},
  journal={Journal of Endocrinological Investigation},
  year={1988},
  volume={11},
  pages={273-278}
}
In six healthy male volunteers, the percutaneous absorption of spironolactone was compared with placebo in a double-blind crossover study. The subjects were randomly given either a cream containing 5% spironolactone or placebo to be applied in a randomized sequential way to a well defined skin area equivalent to 55% of body area. During the 72 h following the application of the ointment, blood levels of canrenone, the major metabolite of spironolactone, have been determined. In order to… Expand
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