Lack of embryotoxicity of fumonisin B1 in New Zealand white rabbits.

  title={Lack of embryotoxicity of fumonisin B1 in New Zealand white rabbits.},
  author={J B L{\'a}borde and Kate Terry and Paul C. Howard and James J. Chen and Thomas F X Collins and Mary E Shackelford and Deborah K. Hansen},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={40 1},
Fumonisin B1 (FB1) is one of a number of mycotoxins produced by fungi, especially Fusarium sp. As a contaminant of many maize-derived products, this toxin is associated with a variety of animal diseases, including esophageal cancer and possibly neural tube defects in humans. We have investigated the embryotoxic potential of this compound in New Zealand White rabbits. Animals were dosed by gavage daily on GD 3-19 with purified FB1 at 0.10, 0.50, or 1.00 mg/kg/day. Maternal lethality occurred at… CONTINUE READING
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