Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia.

@article{Hendrickx1998LackOE,
  title={Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia.},
  author={Ellen Hendrickx and Sonia del Pilar Agudelo and Diana Mu{\~n}oz and Juan Alberto Puerta and I D V{\'e}lez Bernal},
  journal={The American journal of tropical medicine and hygiene},
  year={1998},
  volume={59 6},
  pages={889-92}
}
In a nonblinded, therapeutic trial conducted in Colombia, 1.25-1.5 grams of mefloquine base given as a single oral dose or as 250 mg a day for 5-6 consecutive days was not efficacious in the treatment of New World cutaneous leishmaniasis. The drug had cured only 30.8 % of patients with leishmaniasis skin lesions by the 10th week after start of therapy as compared with a 27.9% complete cicatrization rate in historical controls treated with placebo tablets and an 86.3% cicatrization rate in… CONTINUE READING

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