Lack of efficacy of high-dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection.

@article{Dimaano2007LackOE,
  title={Lack of efficacy of high-dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection.},
  author={Efren M. Dimaano and Mitsuo Saito and Shoko Honda and Edna A Miranda and Maria Terrese G Alonzo and Myra D Valerio and Cynthia A. Mapua and Shingo Inoue and Atsushi Kumaori and Ronald Roll Matias and F. Natividad and Kazunori Oishi},
  journal={The American journal of tropical medicine and hygiene},
  year={2007},
  volume={77 6},
  pages={1135-8}
}
Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery… CONTINUE READING