Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial.

@article{Cantekin1983LackOE,
  title={Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial.},
  author={Erdem I. Cantekin and Ellen M. Mandel and Charles D. Bluestone and Howard E. Rockette and Jack L. Paradise and Sylvan E Stool and T J Fria and Kenneth D. Rogers},
  journal={The New England journal of medicine},
  year={1983},
  volume={308 6},
  pages={297-301}
}
In a double-blind, randomized trial of 553 infants and children who had otitis media with effusion ("secretory" otitis media), we compared the efficacy of a four-week course of an oral decongestant-antihistamine combination (pseudoephedrine hydrochloride, 4 mg per kilogram of body weight per day, and chlorpheniramine maleate, 0.35 mg per kilogram per day) with that of placebo. Among patients with initially unilateral disease, resolution of middle-ear effusion occurred at four weeks in 38 per… CONTINUE READING

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