Lack of effects of tetracaine in rat nucleus paragigantocellularis (PGC) on analgesia from periqueductal gray (PAG) met-enkephalin (ME) injections (in raphe magnus-blocking doses), and on baseline tail-flick latency.

@article{Rosenfeld1994LackOE,
  title={Lack of effects of tetracaine in rat nucleus paragigantocellularis (PGC) on analgesia from periqueductal gray (PAG) met-enkephalin (ME) injections (in raphe magnus-blocking doses), and on baseline tail-flick latency.},
  author={J. Peter Rosenfeld and Lang Yan Xia},
  journal={The International journal of neuroscience},
  year={1994},
  volume={74 1-4},
  pages={
          161-75
        }
}
We showed previously that (1 microgram) tetracaine block of PAG prevents the analgesic effect of PGC-ME injections, and also produces hyperalgesia regarding baseline tail-flick latencies. In the present study we injected PGC (unilaterally and bilaterally) with tetracaine so as to study its possible role in tonic descending inhibition of pain, as well as its necessity for analgesia due to PAG opiate injection. Two micrograms of tetracaine in PGC unilaterally or bilaterally failed to affect… CONTINUE READING
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