Lack of effect of tumor necrosis factor-alpha -308 G/A polymorphism on severity of liver fibrosis in Tunisian hepatitis C virus (HCV)-infected patients.

@article{Bouzgarrou2010LackOE,
  title={Lack of effect of tumor necrosis factor-alpha -308 G/A polymorphism on severity of liver fibrosis in Tunisian hepatitis C virus (HCV)-infected patients.},
  author={Nadia Bouzgarrou and E. Ben Hassen and Sallouha Gabbouj and Evelyne Schvoerer and Nabyl Ben Mami and Hinda Triki and Lotfi Chouchane},
  journal={Gastroenterologie clinique et biologique},
  year={2010},
  volume={34 4-5},
  pages={297-304}
}
OBJECTIVES Tumor necrosis factor alpha (TNF-alpha) plays a key role in the immune response. An elevated plasma level of TNF-alpha was repeatedly observed in patients with active liver injury or cirrhosis regardless of the aetiology. The G/A transition at position -308 in the promoter region have been shown to influence TNF-alpha expression. In this study, we aimed to evaluate the impact of TNF-alpha -308 G/A functional polymorphism on fibrosis severity in Tunisian Hepatitis C Virus (HCV… CONTINUE READING