Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells.

@article{Jakupovic2004LackOE,
  title={Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells.},
  author={Ira Jakupovic and Victoria L Grandage and David Christopher Linch and Asim Ijaz Khwaja},
  journal={Blood},
  year={2004},
  volume={103 8},
  pages={
          3230-2
        }
}
The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist. In addition, it has been reported to be a potent direct activator of apoptosis in primary human acute myeloid leukemia (AML) cells. We have confirmed the ability of E21R to neutralize the biologic effects of GM-CSF and investigated its activity on primary AML blasts. We find that it failed to induce cell death in blast cells from… CONTINUE READING

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