Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial

@inproceedings{Mendelson2010LackOE,
  title={Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial},
  author={John E. Mendelson and Jeremy R. Coyle and Juan Carlos L{\'o}pez and Matthew J. Baggott and Keith Flower and E. Thomas Everhart and Thomas A. Munro and Gantt P. Galloway and Bruce M Cohen},
  booktitle={Psychopharmacology},
  year={2010}
}
Salvinorin A (SA) is a highly selective kappa opioid receptor agonist and the putative psychoactive compound in Salvia divinorum (SD), an increasingly abused hallucinogenic plant. The objectives of this study were to characterize the physiological and subjective effects of SA versus placebo and measure drug and metabolite levels. Sublingual SA doses up to 4 mg were administered in dimethyl sulfoxide/polyethylene glycol 400 solution to eight SD-experienced subjects using a placebo-controlled… CONTINUE READING

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