Lack of effect of rosiglitazone on the pharmacokinetics of oral contraceptives in healthy female volunteers.

@article{Inglis2001LackOE,
  title={Lack of effect of rosiglitazone on the pharmacokinetics of oral contraceptives in healthy female volunteers.},
  author={A M Inglis and Ann K. Miller and Kathleen Thompson Culkin and Dan Finnerty and Scott Patterson and Diane K. Jorkasky and Martin I. Freed},
  journal={Journal of clinical pharmacology},
  year={2001},
  volume={41 6},
  pages={683-90}
}
The effect of rosiglitazone (Avandia [BRL 49653C]) on the pharmacokinetics of ethinylestradiol and norethindrone was evaluated after repeat dosing of rosiglitazone with an oral contraceptive (OC; Ortho-Novum 1/35 containing norethindrone 1 mg and ethinylestradiol 0.035 mg) in a randomized, double-blind, placebo-controlled crossover study. Thirty-four healthy female volunteers received oral rosiglitazone (RSG) 8 mg + OC or matched placebo (P) + OC daily on days 1 to 14 of a 28-day OC dosing… CONTINUE READING

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