Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain.

@article{Tan1998LackOE,
  title={Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain.},
  author={Jasmine Shi Min Tan and Stefan Bluml and Thanh C. Hoang and David J. Dubowitz and G Mevenkamp and Brian D. Ross},
  journal={Magnetic resonance in medicine},
  year={1998},
  volume={39 6},
  pages={1005-10}
}
Recent reports suggest that oral choline supplement may alter the cerebral choline/creatine (Cho/Cr) ratio and might be used to treat neurodegenerative disorders of cholinergic transmission. Using both 1H and 31P MRS, we reexamined the Cho/Cr ratio and quantified cerebral choline and its major constituents: phosphoethanolamine (PE), phosphorylcholine (PC), glycerophosphorylethanolamine (GPE), and glycerophosphorylcholine (GPC). In the four brain locations examined, no significant increases in… CONTINUE READING
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