Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.

  title={Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.},
  author={Charles H. Hennekens and Julie E. Buring and JoAnn E. Manson and Meir J. Stampfer and Bernard A Rosner and N. R. Cook and Charlene Belanger and Frances LaMotte and J. Michael Gaziano and Paul M. Ridker and Walter C. Willett and Richard Peto},
  journal={The New England journal of medicine},
  volume={334 18},
BACKGROUND Observational studies suggest that people who consume more fruits and vegetables containing beta carotene have somewhat lower risks of cancer and cardiovascular disease, and earlier basic research suggested plausible mechanisms. Because large randomized trials of long duration were necessary to test this hypothesis directly, we conducted a trial of beta carotene supplementation. METHODS In a randomized, double-blind, placebo-controlled trial of beta carotene (50 mg on alternate… 

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