Lack of effect of histamine H2-receptor antagonists on indocyanine green disposition measured by two methods.

@article{Donn1984LackOE,
  title={Lack of effect of histamine H2-receptor antagonists on indocyanine green disposition measured by two methods.},
  author={Karl H. Donn and Jonathan Richard Powell and John Farrand Rogers and John R. Plachetka},
  journal={Journal of clinical pharmacology},
  year={1984},
  volume={24 8-9},
  pages={
          360-70
        }
}
Eleven healthy male volunteers were treated according to a randomized, crossover design with ranitidine (300 mg/day), cimetidine (1200 mg/day), or nothing for 48 hours. Ninety minutes after the 48-hour dose, each volunteer was given 0.5 mg/kg indocyanine green by iv bolus. Indocyanine green plasma concentrations were measured by the traditional spectrophotometric method at 800 nm and by HPLC simultaneously monitored at 214 and 656 nm. Neither histamine H2-receptor antagonist altered the… CONTINUE READING