Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients.

@article{Galant2003LackOE,
  title={Lack of effect of fluticasone propionate aqueous nasal spray on the hypothalamic-pituitary-adrenal axis in 2- and 3-year-old patients.},
  author={Stanley P Galant and Isaac R Melamed and Anjuli S Nayak and Kathryn V. Blake and Barbara A. Prillaman and Kenneth D Reed and Cindy Cook and Edward E Philpot and Kathleen A Rickard},
  journal={Pediatrics},
  year={2003},
  volume={112 1 Pt 1},
  pages={96-100}
}
OBJECTIVE Fluticasone propionate aqueous nasal spray (FP) at the highest recommended doses does not affect hypothalamic-pituitary-adrenal (HPA) axis function in adults or older children, but its potential effects in children younger than 4 years have not been previously studied. This randomized, double-blind, placebo-controlled study evaluated the effects of FP on HPA axis function measured by 12-hour urinary-free cortisol levels in children 2 to 3 years of age. METHODS Patients ages 2 to 3… CONTINUE READING
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