Lack of effect of a single dose of ketoconazole on the pharmacokinetics of citalopram.

Abstract

STUDY OBJECTIVE To determine whether the pharmacokinetics of the antidepressant citalopram are affected by ketoconazole, a potent inhibitor of cytochrome P450 (CYP) 3A4. DESIGN Single-center, double-blind, randomized, three-way crossover trial. SETTING Research facility. PARTICIPANTS Eighteen healthy male and female volunteers. INTERVENTION Subjects… (More)

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