Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.

@article{Bhagwagar2003LackOE,
  title={Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.},
  author={Zubin Bhagwagar and Andrew J. Montgomery and Paul M. Grasby and Philip J. Cowen},
  journal={Biological psychiatry},
  year={2003},
  volume={54 9},
  pages={890-5}
}
BACKGROUND Elevated cortisol levels might account for the reduction in central serotonin 1A (5-hydroxytryptamine [5-HT](1A)) receptor binding and function observed in patients with major depression. We tested this hypothesis by studying the effect of acute administration of hydrocortisone on 5-HT(1A) receptor binding potential (BP) in subjects recovered from depression. METHODS We studied 14 subjects (8 male, 6 female) who had recovered from at least two episodes of major depression and had… CONTINUE READING

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